EXPLOITING THE YEAST L-A VIRAL CAPSID FOR THE IN VIVO ASSEMBLY OF CHIMERIC VLPS AS PLATFORM IN VACCINE DEVELOPMENT AND FOREIGN PROTEIN EXPRESSION.

Exploiting the yeast L-A viral capsid for the in vivo assembly of chimeric VLPs as platform in vaccine development and foreign protein expression.

A novel expression system based on engineered variants of the yeast (Saccharomyces cerevisiae) dsRNA virus L-A was developed allowing the in vivo assembly of chimeric virus-like particles (VLPs) as a unique platform for a wide range of applications.We show that polypeptides fused to the viral capsid protein Gag self-assemble into isometric VLP chim

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An atlas of robust microbiome associations with phenotypic traits based on large-scale cohorts from two continents.

Numerous human conditions are associated with the microbiome, yet studies are inconsistent as to the magnitude of the associations and the bacteria involved, likely reflecting insufficiently employed sample sizes.Here, we collected diverse Learning Toys phenotypes and gut microbiota from 34,057 individuals from Israel and the U.S.Analyzing these da

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TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State

Inborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years.Until recently, only recessive mutations were described which, although resulted in Dog Beds severe multisystem syndromes, did not predispose to cancer onset.In the last ten years, a causal role in carcinogenesis has been documented for inherited

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